Combined genetic and transcriptome analysis of patients with SLE: distinct, targetable signatures for susceptibility and severity

OBJECTIVES: Systemic lupus erythematosus (SLE) diagnosis and treatment remain empirical and the molecular basis for its heterogeneity elusive. We explored the genomic basis for disease susceptibility and severity. METHODS: mRNA sequencing and genotyping in blood from 142 patients with SLE and 58 hea...

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Dades bibliogràfiques
Autors principals: Panousis, Nikolaos I, Bertsias, George K, Ongen, Halit, Gergianaki, Irini, Tektonidou, Maria G, Trachana, Maria, Romano-Palumbo, Luciana, Bielser, Deborah, Howald, Cedric, Pamfil, Cristina, Fanouriakis, Antonis, Kosmara, Despoina, Repa, Argyro, Sidiropoulos, Prodromos, Dermitzakis, Emmanouil T, Boumpas, Dimitrios T
Format: Online Article Text
Idioma:English
Publicat: BMJ Publishing Group 2019
Matèries:
Systemic Lupus Erythematosus
Accés en línia:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691930/
https://www.ncbi.nlm.nih.gov/pubmed/31167757
http://dx.doi.org/10.1136/annrheumdis-2018-214379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691930/
https://www.ncbi.nlm.nih.gov/pubmed/31167757
http://dx.doi.org/10.1136/annrheumdis-2018-214379

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