The oncoprotein DEK affects the outcome of PARP1/2 inhibition during mild replication stress

DNA replication stress is a major source of genomic instability and is closely linked to tumor formation and progression. Poly(ADP-ribose)polymerases1/2 (PARP1/2) enzymes are activated in response to replication stress resulting in poly(ADP-ribose) (PAR) synthesis. PARylation plays an important role...

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Detalles Bibliográficos
Autores principales: Ganz, Magdalena, Vogel, Christopher, Czada, Christina, Jörke, Vera, Gwosch, Eva Christina, Kleiner, Rebecca, Pierzynska-Mach, Agnieszka, Zanacchi, Francesca Cella, Diaspro, Alberto, Kappes, Ferdinand, Bürkle, Alexander, Ferrando-May, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692024/
https://www.ncbi.nlm.nih.gov/pubmed/31408463
http://dx.doi.org/10.1371/journal.pone.0213130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692024/
https://www.ncbi.nlm.nih.gov/pubmed/31408463
http://dx.doi.org/10.1371/journal.pone.0213130

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