Hsp70 and DNAJA2 limit CFTR levels through degradation

Cystic Fibrosis is caused by mutations in the CFTR anion channel, many of which cause its misfolding and degradation. CFTR folding depends on the Hsc70 and Hsp70 chaperones and their co-chaperone DNAJA1, but Hsc70/Hsp70 is also involved in CFTR degradation. Here, we address how these opposing functi...

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Detalles Bibliográficos
Autores principales: Kim Chiaw, Patrick, Hantouche, Christine, Wong, Michael J. H., Matthes, Elizabeth, Robert, Renaud, Hanrahan, John W., Shrier, Alvin, Young, Jason C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692068/
https://www.ncbi.nlm.nih.gov/pubmed/31408507
http://dx.doi.org/10.1371/journal.pone.0220984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692068/
https://www.ncbi.nlm.nih.gov/pubmed/31408507
http://dx.doi.org/10.1371/journal.pone.0220984

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