The HCN Channel Voltage Sensor Undergoes A Large Downward Motion During Hyperpolarization

Voltage-gated ion channels (VGICs) contain positively-charged residues within the S4 helix of the voltage-sensing domain (VSD) that are displaced in response to changes in transmembrane voltage, promoting conformational changes that open the pore. Pacemaker HCN channels are unique among VGICs becaus...

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Detalles Bibliográficos
Autores principales: Dai, Gucan, Aman, Teresa K., DiMaio, Frank, Zagotta, William N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692172/
https://www.ncbi.nlm.nih.gov/pubmed/31285608
http://dx.doi.org/10.1038/s41594-019-0259-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692172/
https://www.ncbi.nlm.nih.gov/pubmed/31285608
http://dx.doi.org/10.1038/s41594-019-0259-1

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