Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts

Chronic mitochondrial stress associates with major neurodegenerative diseases. Recovering stressed mitochondria constitutes a critical step of mitochondrial quality control and thus energy maintenance in early stages of neurodegeneration. Here, we reveal Mul1-Mfn2 pathway that maintains neuronal mit...

Descripción completa

Detalles Bibliográficos
Autores principales: Puri, Rajat, Cheng, Xiu-Tang, Lin, Mei-Yao, Huang, Ning, Sheng, Zu-Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692330/
https://www.ncbi.nlm.nih.gov/pubmed/31409786
http://dx.doi.org/10.1038/s41467-019-11636-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692330/
https://www.ncbi.nlm.nih.gov/pubmed/31409786
http://dx.doi.org/10.1038/s41467-019-11636-5

Ejemplares similares