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De novo regulation of RD3 synthesis in residual neuroblastoma cells after intensive multi-modal clinical therapy harmonizes disease evolution

Most high-risk neuroblastomas that initially respond to therapy will ultimately relapse. Currently, no curative treatment is available. Acquired genetic/molecular rearrangement in therapy-resistant cells contributes to tumor relapse. Recently, we identified significant RD3 loss in progressive diseas...

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Detalles Bibliográficos
Autores principales: Somasundaram, Dinesh Babu, Subramanian, Karthikeyan, Aravindan, Sheeja, Yu, Zhongxin, Natarajan, Mohan, Herman, Terence, Aravindan, Natarajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692366/
https://www.ncbi.nlm.nih.gov/pubmed/31409909
http://dx.doi.org/10.1038/s41598-019-48034-2