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Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns
Human pre-catalytic spliceosomes contain several proteins that associate transiently just prior to spliceosome activation and are absent in yeast, suggesting that this critical step is more complex in higher eukaryotes. We demonstrate via RNAi coupled with RNA-Seq that two of these human-specific pr...
Autores principales: | Keiper, Sandra, Papasaikas, Panagiotis, Will, Cindy L., Valcárcel, Juan, Girard, Cyrille, Lührmann, Reinhard |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692369/ https://www.ncbi.nlm.nih.gov/pubmed/31409787 http://dx.doi.org/10.1038/s41467-019-11293-8 |
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