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Validation of [(125)I]CPCR4.3 as an investigative tool for the sensitive and specific detection of hCXCR4 and mCXCR4 expression in vitro and in vivo

BACKGROUND: The development and clinical translation of [(68)Ga] Pentixafor has substantially promoted the relevance of non-invasive PET imaging of CXCR4 expression in a broad spectrum of diseases, including cancer and inflammation. Its pronounced selectivity for the human receptor (hCXCR4), however...

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Detalles Bibliográficos
Autores principales: Schottelius, Margret, Ludescher, Marina, Richter, Frauke, Kapp, Tobias G., Kessler, Horst, Wester, Hans-Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692420/
https://www.ncbi.nlm.nih.gov/pubmed/31410585
http://dx.doi.org/10.1186/s13550-019-0545-2