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Ambroxol Hydrochloride Improves Motor Functions and Extends Survival in a Mouse Model of Familial Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a multifactorial and fatal neurodegenerative disease. Growing evidence connects sphingolipid metabolism to the pathophysiology of ALS. In particular, levels of ceramides, glucosylceramides, and gangliosides are dysregulated in the central nervous system and at...

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Detalles Bibliográficos
Autores principales:	Bouscary, Alexandra, Quessada, Cyril, Mosbach, Althéa, Callizot, Noëlle, Spedding, Michael, Loeffler, Jean-Philippe, Henriques, Alexandre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692493/ https://www.ncbi.nlm.nih.gov/pubmed/31447678 http://dx.doi.org/10.3389/fphar.2019.00883

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