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Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1
BACKGROUND: Epigenetic clocks are mathematical models that predict the biological age of an individual using DNA methylation data and have emerged in the last few years as the most accurate biomarkers of the aging process. However, little is known about the molecular mechanisms that control the rate...
Autores principales: | Martin-Herranz, Daniel E., Aref-Eshghi, Erfan, Bonder, Marc Jan, Stubbs, Thomas M., Choufani, Sanaa, Weksberg, Rosanna, Stegle, Oliver, Sadikovic, Bekim, Reik, Wolf, Thornton, Janet M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693144/ https://www.ncbi.nlm.nih.gov/pubmed/31409373 http://dx.doi.org/10.1186/s13059-019-1753-9 |
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