Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2(+ve) breast cancer metastasis

BACKGROUND: Human epidermal growth factor receptor-2 (HER2)-targeted therapies prolong survival in HER2-positive breast cancer patients. Benefit stems primarily from improved control of systemic disease, but up to 50% of patients progress to incurable brain metastases due to acquired resistance and/...

Descripción completa

Detalles Bibliográficos
Autores principales: Nagpal, Aadya, Redvers, Richard P., Ling, Xiawei, Ayton, Scott, Fuentes, Miriam, Tavancheh, Elnaz, Diala, Irmina, Lalani, Alshad, Loi, Sherene, David, Steven, Anderson, Robin L., Smith, Yvonne, Merino, Delphine, Denoyer, Delphine, Pouliot, Normand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693253/
https://www.ncbi.nlm.nih.gov/pubmed/31409375
http://dx.doi.org/10.1186/s13058-019-1177-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693253/
https://www.ncbi.nlm.nih.gov/pubmed/31409375
http://dx.doi.org/10.1186/s13058-019-1177-1

Ejemplares similares