Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability

THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome instability. Here, we show that human THO interacts with MFAP1 (microfibrillar-associated protein 1), a spliceosome-associated factor. Interestingly, MFAP1 depletion impairs ce...

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Detalles Bibliográficos
Autores principales: Salas-Armenteros, Irene, Barroso, Sonia I., Rondón, Ana G., Pérez, Mónica, Andújar, Eloisa, Luna, Rosa, Aguilera, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693559/
https://www.ncbi.nlm.nih.gov/pubmed/31390568
http://dx.doi.org/10.1016/j.celrep.2019.07.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693559/
https://www.ncbi.nlm.nih.gov/pubmed/31390568
http://dx.doi.org/10.1016/j.celrep.2019.07.010

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