Aberrant Transcriptional Regulation of Super-enhancers by RET Finger Protein-histone Deacetylase 1 Complex in Glioblastoma: Chemoresistance to Temozolomide

Glioblastoma (GBM), the most common primary brain tumor, is the most aggressive human cancers, with a median survival rate of only 14.6 months. Temozolomide (TMZ) is the frontline chemotherapeutic drug in GBM. Drug resistance is the predominant obstacle in TMZ therapy. Drug resistance occurs via mul...

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Detalles Bibliográficos
Autores principales: NATSUME, Atsushi, HIRANO, Masaki, RANJIT, Melissa, AOKI, Kosuke, WAKABAYASHI, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Neurosurgical Society 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694022/
https://www.ncbi.nlm.nih.gov/pubmed/31178471
http://dx.doi.org/10.2176/nmc.ra.2019-0049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694022/
https://www.ncbi.nlm.nih.gov/pubmed/31178471
http://dx.doi.org/10.2176/nmc.ra.2019-0049

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