A Polygenic Lipodystrophy Genetic Risk Score Characterizes Risk Independent of BMI in the Diabetes Prevention Program

CONTEXT: There is substantial heterogeneity in insulin sensitivity, and genetics may suggest possible mechanisms by which common variants influence this trait. OBJECTIVES: We aimed to evaluate an 11-variant polygenic lipodystrophy genetic risk score (GRS) for association with anthropometric, glycemi...

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Detalles Bibliográficos
Autores principales: Srinivasan, Shylaja, Jablonski, Kathleen A, Knowler, William C, Dagogo-Jack, Samuel, E. Kahn, Steven, Boyko, Edward J, Bray, George A, Horton, Edward S, Hivert, Marie-France, Goldberg, Ronald, Chen, Ling, Mercader, Josep, Harden, Maegan, Florez, Jose C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Clinical Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694040/
https://www.ncbi.nlm.nih.gov/pubmed/31428720
http://dx.doi.org/10.1210/js.2019-00069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694040/
https://www.ncbi.nlm.nih.gov/pubmed/31428720
http://dx.doi.org/10.1210/js.2019-00069

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