Intrabody against prolyl hydroxylase 2 promotes angiogenesis by stabilizing hypoxia-inducible factor-1α

Hypoxia-inducible factor (HIF)-1α is a crucial transcription factor that regulates the expression of target genes involved in angiogenesis. Prolyl hydroxylase 2 (PHD2) dominantly hydroxylates two highly conserved proline residues of HIF-1α to promote its degradation. This study was designed to const...

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Detalles Bibliográficos
Autores principales: Zhao, Liangzhong, Liu, Ziyu, Yang, Fang, Zhang, Ying, Xue, Ying, Miao, Haipeng, Liao, Xiangzhi, Huang, Hongli, Li, Guiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694103/
https://www.ncbi.nlm.nih.gov/pubmed/31413262
http://dx.doi.org/10.1038/s41598-019-47891-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694103/
https://www.ncbi.nlm.nih.gov/pubmed/31413262
http://dx.doi.org/10.1038/s41598-019-47891-1

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