Flux balance analysis with or without molecular crowding fails to predict two thirds of experimentally observed epistasis in yeast

Computational predictions of double gene knockout effects by flux balance analysis (FBA) have been used to characterized genome-wide patterns of epistasis in microorganisms. However, it is unclear how in silico predictions are related to in vivo epistasis, as FBA predicted only a minority of experim...

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Detalles Bibliográficos
Autores principales: Alzoubi, Deya, Desouki, Abdelmoneim Amer, Lercher, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694147/
https://www.ncbi.nlm.nih.gov/pubmed/31413270
http://dx.doi.org/10.1038/s41598-019-47935-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694147/
https://www.ncbi.nlm.nih.gov/pubmed/31413270
http://dx.doi.org/10.1038/s41598-019-47935-6

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