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Flux balance analysis with or without molecular crowding fails to predict two thirds of experimentally observed epistasis in yeast
Computational predictions of double gene knockout effects by flux balance analysis (FBA) have been used to characterized genome-wide patterns of epistasis in microorganisms. However, it is unclear how in silico predictions are related to in vivo epistasis, as FBA predicted only a minority of experim...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694147/ https://www.ncbi.nlm.nih.gov/pubmed/31413270 http://dx.doi.org/10.1038/s41598-019-47935-6 |