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Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer

BACKGROUND: Prostate cancer is poorly responsive to immune checkpoint inhibition, yet a combination with radiotherapy may enhance the immune response. In this study, we combined radiotherapy with immune checkpoint inhibition (iRT) in a castration-resistant prostate cancer (CRPC) preclinical model. M...

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Detalles Bibliográficos
Autores principales: Dudzinski, Stephanie O., Cameron, Brent D., Wang, Jian, Rathmell, Jeffrey C., Giorgio, Todd D., Kirschner, Austin N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694548/
https://www.ncbi.nlm.nih.gov/pubmed/31412954
http://dx.doi.org/10.1186/s40425-019-0704-z