Uric acid regulates NLRP3/IL-1β signaling pathway and further induces vascular endothelial cells injury in early CKD through ROS activation and K(+) efflux

BACKGROUND: Chronic kidney disease (CKD) has been considered as a major health problem in the world. Increasing uric acid (UA) could induce vascular endothelial injury, which is closely related to microinflammation, oxidative stress, and disorders of lipids metabolism. However, the specific mechanis...

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Detalles Bibliográficos
Autores principales: Yin, Wei, Zhou, Qiao-Ling, OuYang, Sha-Xi, Chen, Ying, Gong, Yu-Ting, Liang, Yu-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694569/
https://www.ncbi.nlm.nih.gov/pubmed/31412804
http://dx.doi.org/10.1186/s12882-019-1506-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694569/
https://www.ncbi.nlm.nih.gov/pubmed/31412804
http://dx.doi.org/10.1186/s12882-019-1506-8

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