Identification of Guide-Intrinsic Determinants of Cas9 Specificity

Considerable effort has been devoted to developing a comprehensive understanding of CRISPR nuclease specificity. In silico predictions and multiple genome-wide cellular and biochemical approaches have revealed a basic understanding of the Cas9 specificity profile. However, none of these approaches h...

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Detalles Bibliográficos
Autores principales: Huston, Nicholas C., Tycko, Josh, Tillotson, Eric L., Wilson, Christopher J., Myer, Vic E., Jayaram, Hariharan, Steinberg, Barrett E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694761/
https://www.ncbi.nlm.nih.gov/pubmed/31225747
http://dx.doi.org/10.1089/crispr.2019.0009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694761/
https://www.ncbi.nlm.nih.gov/pubmed/31225747
http://dx.doi.org/10.1089/crispr.2019.0009

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