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Mck1 defines a key S-phase checkpoint effector in response to various degrees of replication threats

The S-phase checkpoint plays an essential role in regulation of the ribonucleotide reductase (RNR) activity to maintain the dNTP pools. How eukaryotic cells respond appropriately to different levels of replication threats remains elusive. Here, we have identified that a conserved GSK-3 kinase Mck1 c...

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Detalles Bibliográficos
Autores principales: Li, Xiaoli, Jin, Xuejiao, Sharma, Sushma, Liu, Xiaojing, Zhang, Jiaxin, Niu, Yanling, Li, Jiani, Li, Zhen, Zhang, Jingjing, Cao, Qinhong, Hou, Wenya, Du, Li-Lin, Liu, Beidong, Lou, Huiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695201/
https://www.ncbi.nlm.nih.gov/pubmed/31381575
http://dx.doi.org/10.1371/journal.pgen.1008136