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Reduced model to predict thrombin and fibrin during thrombosis on collagen/tissue factor under venous flow: Roles of γ’-fibrin and factor XIa

During thrombosis, thrombin generates fibrin, however fibrin reversibly binds thrombin with low affinity E-domain sites (K(D) = 2.8 μM) and high affinity γ’-fibrin sites (K(D) = 0.1 μM). For blood clotting on collagen/tissue factor (1 TF-molecule/μm(2)) at 200 s(-1) wall shear rate, high μM-levels o...

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Detalles Bibliográficos
Autores principales: Chen, Jason, Diamond, Scott L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695209/
https://www.ncbi.nlm.nih.gov/pubmed/31381558
http://dx.doi.org/10.1371/journal.pcbi.1007266