Cargando…
Reduced model to predict thrombin and fibrin during thrombosis on collagen/tissue factor under venous flow: Roles of γ’-fibrin and factor XIa
During thrombosis, thrombin generates fibrin, however fibrin reversibly binds thrombin with low affinity E-domain sites (K(D) = 2.8 μM) and high affinity γ’-fibrin sites (K(D) = 0.1 μM). For blood clotting on collagen/tissue factor (1 TF-molecule/μm(2)) at 200 s(-1) wall shear rate, high μM-levels o...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695209/ https://www.ncbi.nlm.nih.gov/pubmed/31381558 http://dx.doi.org/10.1371/journal.pcbi.1007266 |