Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response

Disrupting either the DNA annealing factor RAD52 or the A-family DNA polymerase POLQ can cause synthetic lethality with defects in BRCA1 and BRCA2, which are tumor suppressors important for homology-directed repair of DNA double-strand breaks (DSBs), and protection of stalled replication forks. A li...

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Detalles Bibliográficos
Autores principales: Kelso, Andrew A., Lopezcolorado, Felicia Wednesday, Bhargava, Ragini, Stark, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695211/
https://www.ncbi.nlm.nih.gov/pubmed/31381562
http://dx.doi.org/10.1371/journal.pgen.1008319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695211/
https://www.ncbi.nlm.nih.gov/pubmed/31381562
http://dx.doi.org/10.1371/journal.pgen.1008319

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