AMPK activation, eEF2 inactivation, and reduced protein synthesis in the cerebral cortex of hibernating chipmunks

During hibernation, mammalian cells are exposed to severe environmental stressors such as low temperature, lowered O(2) supply, and glucose deficiency. The cellular metabolic rate is markedly reduced for adapting to these conditions. AMP-activated protein kinase (AMPK) senses the cellular energy sta...

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Detalles Bibliográficos
Autores principales: Yamada, Shintaro, Kamata, Taito, Nawa, Hiroyuki, Sekijima, Tsuneo, Takei, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695389/
https://www.ncbi.nlm.nih.gov/pubmed/31417118
http://dx.doi.org/10.1038/s41598-019-48172-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695389/
https://www.ncbi.nlm.nih.gov/pubmed/31417118
http://dx.doi.org/10.1038/s41598-019-48172-7

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