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AMPK activation, eEF2 inactivation, and reduced protein synthesis in the cerebral cortex of hibernating chipmunks
During hibernation, mammalian cells are exposed to severe environmental stressors such as low temperature, lowered O(2) supply, and glucose deficiency. The cellular metabolic rate is markedly reduced for adapting to these conditions. AMP-activated protein kinase (AMPK) senses the cellular energy sta...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695389/ https://www.ncbi.nlm.nih.gov/pubmed/31417118 http://dx.doi.org/10.1038/s41598-019-48172-7 |