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The Effect of Preexisting Immunity on Virus Detection and Immune Responses in a Phase II, Randomized Trial of a Russian-Backbone, Live, Attenuated Influenza Vaccine in Bangladeshi Children

BACKGROUND: In a 2012 Phase II clinical trial, 300 Bangladeshi children aged 24 to 59 months with no prior influenza vaccine exposure were randomized to receive a single intranasally-administered dose of either trivalent, Russian-backbone, live, attenuated influenza vaccine (LAIV) or placebo. Protoc...

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Detalles Bibliográficos
Autores principales: Brickley, Elizabeth B, Wright, Peter F, Khalenkov, Alexey, Neuzil, Kathleen M, Ortiz, Justin R, Rudenko, Larisa, Levine, Min Z, Katz, Jacqueline M, Brooks, W Abdullah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695513/
https://www.ncbi.nlm.nih.gov/pubmed/30481269
http://dx.doi.org/10.1093/cid/ciy1004