Olmesartan Attenuates Kidney Fibrosis in a Murine Model of Alport Syndrome by Suppressing Tubular Expression of TGFβ

Despite the wide use of angiotensin II receptor blockers in the treatment of Alport syndrome (AS), the mechanism as to how angiotensin II receptor blockers prevent interstitial fibrosis remains unclear. Here, we report that treatment of olmesartan effectively targets the feedback loop between the re...

Descripción completa

Detalles Bibliográficos
Autores principales: Suh, Sang Heon, Choi, Hong Sang, Kim, Chang Seong, Kim, In Jin, Ma, Seong Kwon, Scholey, James W., Kim, Soo Wan, Bae, Eun Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695622/
https://www.ncbi.nlm.nih.gov/pubmed/31390839
http://dx.doi.org/10.3390/ijms20153843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695622/
https://www.ncbi.nlm.nih.gov/pubmed/31390839
http://dx.doi.org/10.3390/ijms20153843

Ejemplares similares