Bioluminescence Resonance Energy Transfer Based G Protein-Activation Assay to Probe Duration of Antagonism at the Histamine H(3) Receptor

Duration of receptor antagonism, measured as the recovery of agonist responsiveness, is gaining attention as a method to evaluate the ‘effective’ target-residence for antagonists. These functional assays might be a good alternative for kinetic binding assays in competition with radiolabeled or fluor...

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Detalles Bibliográficos
Autores principales: Mocking, Tamara A. M., Buzink, Maurice C. M. L., Leurs, Rob, Vischer, Henry F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695674/
https://www.ncbi.nlm.nih.gov/pubmed/31366084
http://dx.doi.org/10.3390/ijms20153724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695674/
https://www.ncbi.nlm.nih.gov/pubmed/31366084
http://dx.doi.org/10.3390/ijms20153724

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