Application of a Substrate-Mediated Selection with c-Src Tyrosine Kinase to a DNA-Encoded Chemical Library

As aberrant activity of protein kinases is observed in many disease states, these enzymes are common targets for therapeutics and detection of activity levels. The development of non-natural protein kinase substrates offers an approach to protein substrate competitive inhibitors, a class of kinase i...

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Detalles Bibliográficos
Autores principales: Kim, Dongwook, Sun, Yixing, Xie, Dan, Denton, Kyle E., Chen, Hao, Lin, Hang, Wendt, Michael K., Post, Carol Beth, Krusemark, Casey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695731/
https://www.ncbi.nlm.nih.gov/pubmed/31366048
http://dx.doi.org/10.3390/molecules24152764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695731/
https://www.ncbi.nlm.nih.gov/pubmed/31366048
http://dx.doi.org/10.3390/molecules24152764

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