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Mitochondria-Targeting Antioxidant Provides Cardioprotection through Regulation of Cytosolic and Mitochondrial Zn(2+) Levels with Re-Distribution of Zn(2+)-Transporters in Aged Rat Cardiomyocytes
Aging is an important risk factor for cardiac dysfunction. Heart during aging exhibits a depressed mechanical activity, at least, through mitochondria-originated increases in ROS. Previously, we also have shown a close relationship between increased ROS and cellular intracellular free Zn(2+) ([Zn(2+...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695787/ https://www.ncbi.nlm.nih.gov/pubmed/31382470 http://dx.doi.org/10.3390/ijms20153783 |