Revisiting the Allosteric Regulation of Sodium Cation on the Binding of Adenosine at the Human A(2A) Adenosine Receptor: Insights from Supervised Molecular Dynamics (SuMD) Simulations

One of the most intriguing findings highlighted from G protein-coupled receptor (GPCR) crystallography is the presence, in many members of class A, of a partially hydrated sodium ion in the middle of the seven transmembrane helices (7TM) bundle. In particular, the human adenosine A(2A) receptor (A(2...

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Detalles Bibliográficos
Autores principales: Bissaro, Maicol, Bolcato, Giovanni, Deganutti, Giuseppe, Sturlese, Mattia, Moro, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695830/
https://www.ncbi.nlm.nih.gov/pubmed/31362426
http://dx.doi.org/10.3390/molecules24152752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695830/
https://www.ncbi.nlm.nih.gov/pubmed/31362426
http://dx.doi.org/10.3390/molecules24152752

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