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Downregulation of STAT3, β-Catenin, and Notch-1 by Single and Combinations of siRNA Treatment Enhance Chemosensitivity of Wild Type and Doxorubicin Resistant MCF7 Breast Cancer Cells to Doxorubicin
Combinatorial therapeutic strategies using siRNA and small molecules to eradicate tumors are emerging. Targeting multiple signaling pathways decreases the chances of cancer cells switching and adapting new signaling processes that may occur when using a single therapeutic modality. Aberrant function...
Autores principales: | Alshaer, Walhan, Alqudah, Dana A., Wehaibi, Suha, Abuarqoub, Duaa, Zihlif, Malek, Hatmal, Ma’mon M., Awidi, Abdalla |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696135/ https://www.ncbi.nlm.nih.gov/pubmed/31357721 http://dx.doi.org/10.3390/ijms20153696 |
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