Structural Optimization and Structure–Activity Relationship of 4-Thiazolidinone Derivatives as Novel Inhibitors of Human Dihydroorotate Dehydrogenase

Human dihydroorotate dehydrogenase (hDHODH), one of the attractive targets for the development of immunosuppressive drugs, is also a potential target of anticancer drugs and anti-leukemic drugs. The development of promising hDHODH inhibitors is in high demand. Based on the unique binding mode of our...

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Detalles Bibliográficos
Autores principales: Zeng, Fanxun, Quan, Lina, Yang, Guantian, Qi, Tiantian, Zhang, Letian, Li, Shiliang, Li, Honglin, Zhu, Lili, Xu, Xiaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696179/
https://www.ncbi.nlm.nih.gov/pubmed/31370178
http://dx.doi.org/10.3390/molecules24152780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696179/
https://www.ncbi.nlm.nih.gov/pubmed/31370178
http://dx.doi.org/10.3390/molecules24152780

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