Cargando…

Structural Optimization and Structure–Activity Relationship of 4-Thiazolidinone Derivatives as Novel Inhibitors of Human Dihydroorotate Dehydrogenase

Human dihydroorotate dehydrogenase (hDHODH), one of the attractive targets for the development of immunosuppressive drugs, is also a potential target of anticancer drugs and anti-leukemic drugs. The development of promising hDHODH inhibitors is in high demand. Based on the unique binding mode of our...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Fanxun, Quan, Lina, Yang, Guantian, Qi, Tiantian, Zhang, Letian, Li, Shiliang, Li, Honglin, Zhu, Lili, Xu, Xiaoyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696179/ https://www.ncbi.nlm.nih.gov/pubmed/31370178 http://dx.doi.org/10.3390/molecules24152780

Ejemplares similares

Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis()
por: Zeng, Fanxun, et al.
Publicado: (2021)

Synthesis, Design, and Structure–Activity Relationship of the Pyrimidone Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase
por: Xu, Le, et al.
Publicado: (2018)

Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity
por: Li, Shiliang, et al.
Publicado: (2015)

Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines
por: Horwitz, Samantha M., et al.
Publicado: (2022)

Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum
por: Ross, Leila Saxby, et al.
Publicado: (2018)

Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase
por: Xu, Yechun, et al.
Publicado: (2020)

Identification of Dihydroorotate Dehydrogenase Inhibitors Using the Cell Painting Assay
por: Schölermann, Beate, et al.
Publicado: (2022)

Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target
por: Sato, Dan, et al.
Publicado: (2020)

Crystal structures of FMN‐bound and FMN‐free forms of dihydroorotate dehydrogenase from Trypanosoma brucei
por: Kubota, Tomomi, et al.
Publicado: (2018)

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity
por: Kokkonda, Sreekanth, et al.
Publicado: (2018)

Mysteries of partial dihydroorotate dehydrogenase inhibition and leukemia terminal differentiation
por: Saunthararajah, Yogen
Publicado: (2020)

Combination of consensus and ensemble docking strategies for the discovery of human dihydroorotate dehydrogenase inhibitors
por: Chilingaryan, Garri, et al.
Publicado: (2021)

Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii
por: Russo, Thomas A., et al.
Publicado: (2022)

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors
por: Deng, Xiaoyi, et al.
Publicado: (2014)

ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia
por: Zhou, Jianbiao, et al.
Publicado: (2019)

Molecular docking analysis of Plasmodium falciparum dihydroorotate dehydrogenase towards the design of effective inhibitors
por: Owoloye, Afolabi, et al.
Publicado: (2020)

Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study
por: Galati, Salvatore, et al.
Publicado: (2022)

Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling
por: KAWATANI, MAKOTO, et al.
Publicado: (2023)

Fluorescence assay of dihydroorotate dehydrogenase that may become a cancer biomarker
por: Yin, Sheng, et al.
Publicado: (2017)

Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
por: Houshmand, Mohammad, et al.
Publicado: (2022)

Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia
por: Branstrom, Arthur, et al.
Publicado: (2022)

3D-QSAR Studies on a Series of Dihydroorotate Dehydrogenase Inhibitors: Analogues of the Active Metabolite of Leflunomide
por: Li, Shun-Lai, et al.
Publicado: (2011)

Dihydroorotate dehydrogenase Inhibitors Target c-Myc and Arrest Melanoma, Myeloma and Lymphoma cells at S-phase
por: Dorasamy, Mathura Subangari, et al.
Publicado: (2017)

Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro
por: Kim, Yu-Jin, et al.
Publicado: (2020)

Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition
por: Arnould, Stéphanie, et al.
Publicado: (2017)

Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase
por: Maetani, Micah, et al.
Publicado: (2017)

Therapeutic targeting of both dihydroorotate dehydrogenase and nucleoside transport in MYCN-amplified neuroblastoma
por: Yu, Yajie, et al.
Publicado: (2021)

Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells
por: Wu, Dang, et al.
Publicado: (2018)

A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode
por: Zeng, Ting, et al.
Publicado: (2019)

Design, Synthesis, and Structure–Activity Relationship Study of Potent MAPK11 Inhibitors
por: Gong, Mengdie, et al.
Publicado: (2021)

Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum
por: Dickerman, Benjamin K., et al.
Publicado: (2016)

Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions
por: Miyazaki, Yukiko, et al.
Publicado: (2018)

Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors “leflunomide” and “teriflunomide” in Covid-19: A narrative review
por: Kaur, Hardeep, et al.
Publicado: (2021)

Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase
por: Costeira-Paulo, Joana, et al.
Publicado: (2018)

The target site of the novel fungicide quinofumelin, Pyricularia oryzae class II dihydroorotate dehydrogenase
por: Higashimura, Norikazu, et al.
Publicado: (2022)

Thiazoles and Thiazolidinones as COX/LOX Inhibitors
por: Liaras, Konstantinos, et al.
Publicado: (2018)

A Novel Graph Neural Network Methodology to Investigate Dihydroorotate Dehydrogenase Inhibitors in Small Cell Lung Cancer
por: Zhi, Hong-Yi, et al.
Publicado: (2021)

Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication
por: Stegmann, Kim M., et al.
Publicado: (2022)

Dihydroorotate dehydrogenase inhibition acts synergistically with tyrosine kinase inhibitors to induce apoptosis of mantle cell lymphoma cells
por: Eriksen‐Gjerstad, May, et al.
Publicado: (2022)

The Role of Dihydroorotate Dehydrogenase in Apoptosis Induction in Response to Inhibition of the Mitochondrial Respiratory Chain Complex III
por: Khutornenko, A. A., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_diirpaa774564qpo6vc05a420n