Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells

Checkpoint kinase 1 (CHK1) is a central mediator of the DNA damage response (DDR) at the S and G2/M cell cycle checkpoints, and plays a crucial role in preserving genomic integrity. CHK1 overexpression is thought to contribute to cancer aggressiveness, and several selective inhibitors of this kinase...

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Detalles Bibliográficos
Autores principales: Ando, Kiyohiro, Nakamura, Yohko, Nagase, Hiroki, Nakagawara, Akira, Koshinaga, Tsugumichi, Wada, Satoshi, Makishima, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696225/
https://www.ncbi.nlm.nih.gov/pubmed/31362335
http://dx.doi.org/10.3390/ijms20153700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696225/
https://www.ncbi.nlm.nih.gov/pubmed/31362335
http://dx.doi.org/10.3390/ijms20153700

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