Cargando…

Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells

Checkpoint kinase 1 (CHK1) is a central mediator of the DNA damage response (DDR) at the S and G2/M cell cycle checkpoints, and plays a crucial role in preserving genomic integrity. CHK1 overexpression is thought to contribute to cancer aggressiveness, and several selective inhibitors of this kinase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ando, Kiyohiro, Nakamura, Yohko, Nagase, Hiroki, Nakagawara, Akira, Koshinaga, Tsugumichi, Wada, Satoshi, Makishima, Makoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696225/ https://www.ncbi.nlm.nih.gov/pubmed/31362335 http://dx.doi.org/10.3390/ijms20153700

Ejemplares similares

FGFR2 loss sensitizes MYCN‐amplified neuroblastoma CHP134 cells to CHK1 inhibitor–induced apoptosis
por: Ando, Kiyohiro, et al.
Publicado: (2021)

CEP131 Abrogates CHK1 Inhibitor-Induced Replication Defects and Is Associated with Unfavorable Outcome in Neuroblastoma
por: Ando, Kiyohiro, et al.
Publicado: (2020)

Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells
por: Islam, Mohammad Sazzadul, et al.
Publicado: (2019)

Acceleration or Brakes: Which Is Rational for Cell Cycle-Targeting Neuroblastoma Therapy?
por: Ando, Kiyohiro, et al.
Publicado: (2021)

The RUNX Family Defines Trk Phenotype and Aggressiveness of Human Neuroblastoma through Regulation of p53 and MYCN
por: Ando, Kiyohiro, et al.
Publicado: (2023)

RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response
por: Ozaki, Toshinori, et al.
Publicado: (2013)

Identification of novel candidate compounds targeting TrkB to induce apoptosis in neuroblastoma
por: Nakamura, Yohko, et al.
Publicado: (2014)

Retrospective Analysis of INRG Clinical and Genomic Factors for 605 Neuroblastomas in Japan: A Report from the Japan Children’s Cancer Group Neuroblastoma Committee (JCCG-JNBSG) †
por: Ohira, Miki, et al.
Publicado: (2021)

NLRR1 Is a Potential Therapeutic Target in Neuroblastoma and MYCN-Driven Malignant Cancers
por: Takatori, Atsushi, et al.
Publicado: (2021)

NR4A3, a possibile oncogenic factor for neuroblastoma associated with CpGi methylation within the third exon
por: UEKUSA, SHOTA, et al.
Publicado: (2014)

Oncogenic LMO3 Collaborates with HEN2 to Enhance Neuroblastoma Cell Growth through Transactivation of Mash1
por: Isogai, Eriko, et al.
Publicado: (2011)

Polyethylene glycol derivative 9bw suppresses growth of neuroblastoma cells by inhibiting oxidative phosphorylation
por: Nagasaki‐Maeoka, Eri, et al.
Publicado: (2020)

Loss of p53 suppresses replication stress-induced DNA damage in ATRX-deficient neuroblastoma
por: Akter, Jesmin, et al.
Publicado: (2021)

Functional interplay between MYCN, NCYM, and OCT4 promotes aggressiveness of human neuroblastomas
por: Kaneko, Yoshiki, et al.
Publicado: (2015)

Unfavorable neuroblastoma prognostic factor NLRR2 inhibits cell differentiation by transcriptional induction through JNK pathway
por: Sheikh, Afzal, et al.
Publicado: (2016)

DNA Ligase 4 Contributes to Cell Proliferation against DNA-PK Inhibition in MYCN-Amplified Neuroblastoma IMR32 Cells
por: Ando, Kiyohiro, et al.
Publicado: (2023)

Runt-related transcription factor 2 (RUNX2) inhibits p53-dependent apoptosis through the collaboration with HDAC6 in response to DNA damage
por: Ozaki, T, et al.
Publicado: (2013)

ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastoma
por: Hasan, Md. Kamrul, et al.
Publicado: (2013)

Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis
por: Magni, Martina, et al.
Publicado: (2014)

CHK2 kinase in the DNA damage response and beyond
por: Zannini, Laura, et al.
Publicado: (2014)

Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation
por: Yu, Xinfang, et al.
Publicado: (2020)

Apoptotic Cell Death in Neuroblastoma
por: Li, Yuanyuan, et al.
Publicado: (2013)

NFBD1/MDC1 Is Phosphorylated by PLK1 and Controls G2/M Transition through the Regulation of a TOPOIIα-Mediated Decatenation Checkpoint
por: Ando, Kiyohiro, et al.
Publicado: (2013)

p53 oligomerization status as an indicator of sensitivity of p53-wildtype neuroblastomas to the combination of DNA damaging agent and Chk1 inhibitor
por: Levesque, Aime A., et al.
Publicado: (2022)

Neuronal leucine-rich repeat 1 negatively regulates anaplastic lymphoma kinase in neuroblastoma
por: Satoh, Shunpei, et al.
Publicado: (2016)

Wip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis
por: Chen, Zhenghu, et al.
Publicado: (2016)

JAK Inhibition Prevents DNA Damage and Apoptosis in Testicular Ischemia-Reperfusion Injury via Modulation of the ATM/ATR/Chk Pathway
por: Khashab, Farah, et al.
Publicado: (2021)

Correlation between the International Neuroblastoma Pathology Classification and genomic signature in neuroblastoma
por: Nakazawa, Atsuko, et al.
Publicado: (2015)

A novel technique for measuring variations in DNA copy-number: competitive genomic polymerase chain reaction
por: Iwao-Koizumi, Kyoko, et al.
Publicado: (2007)

Regulated Degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage
por: Park, Caroline, et al.
Publicado: (2015)

Editorial: Neuroblastoma: Signal Crosstalk and Future Insight Into Clinical Trials
por: Ando, Kiyohiro, et al.
Publicado: (2022)

Overexpression of DA41 in v‐Ha‐ras‐3Y1 Cells Causes Growth Suppression
por: Ozaki, Toshinori, et al.
Publicado: (2000)

Obliterative cholangiopathy in acquired cystic biliary atresia type III after cyst perforation: a case report
por: Koshinaga, Tsugumichi, et al.
Publicado: (2018)

Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein
por: Day, Matthew, et al.
Publicado: (2021)

Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells
por: Gao, Yang, et al.
Publicado: (2020)

The Role of MYCN in Symmetric vs. Asymmetric Cell Division of Human Neuroblastoma Cells
por: Izumi, Hideki, et al.
Publicado: (2020)

Chk1, Chk2, is the amplifier on?
por: Dove, Alan W.
Publicado: (2001)

Cyclin D1 Binding Protein 1 Responds to DNA Damage through the ATM–CHK2 Pathway
por: Niwa, Yusuke, et al.
Publicado: (2022)

Phosphorylation-Dependent Interactions between Crb2 and Chk1 Are Essential for DNA Damage Checkpoint
por: Qu, Meng, et al.
Publicado: (2012)

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage
por: Gong, Eun-Yeung, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_3218d7g1vpceacd1bju4ctqi81