LPS-Binding Protein Modulates Acute Renal Fibrosis by Inducing Pericyte-to-Myofibroblast Trans-Differentiation through TLR-4 Signaling

During sepsis, the increased synthesis of circulating lipopolysaccharide (LPS)-binding protein (LBP) activates LPS/TLR4 signaling in renal resident cells, leading to acute kidney injury (AKI). Pericytes are the major source of myofibroblasts during chronic kidney disease (CKD), but their involvement...

Descripción completa

Detalles Bibliográficos
Autores principales: Castellano, Giuseppe, Stasi, Alessandra, Franzin, Rossana, Sallustio, Fabio, Divella, Chiara, Spinelli, Alessandra, Netti, Giuseppe Stefano, Fiaccadori, Enrico, Cantaluppi, Vincenzo, Crovace, Antonio, Staffieri, Francesco, Lacitignola, Luca, Grandaliano, Giuseppe, Simone, Simona, Pertosa, Giovanni Battista, Gesualdo, Loreto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696277/
https://www.ncbi.nlm.nih.gov/pubmed/31357597
http://dx.doi.org/10.3390/ijms20153682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696277/
https://www.ncbi.nlm.nih.gov/pubmed/31357597
http://dx.doi.org/10.3390/ijms20153682

Ejemplares similares