Design, Synthesis and Biological Evaluation of 1-Phenyl-2-(phenylamino) Ethanone Derivatives as Novel MCR-1 Inhibitors

Polymyxins are considered to be the last-line antibiotics that are used to treat infections caused by multidrug-resistant (MDR) gram-negative bacteria; however, the plasmid-mediated transferable colistin resistance gene (mcr-1) has rendered polymyxins ineffective. Therefore, the protein encoded by m...

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Detalles Bibliográficos
Autores principales: Lan, Xiu-juan, Yan, Hai-tao, Lin, Feng, Hou, Shi, Li, Chen-chen, Wang, Guang-shu, Sun, Wei, Xiao, Jun-hai, Li, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696459/
https://www.ncbi.nlm.nih.gov/pubmed/31357453
http://dx.doi.org/10.3390/molecules24152719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696459/
https://www.ncbi.nlm.nih.gov/pubmed/31357453
http://dx.doi.org/10.3390/molecules24152719

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