A Hydroquinone-Based Derivative Elicits Apoptosis and Autophagy via Activating a ROS-Dependent Unfolded Protein Response in Human Glioblastoma

5-Lipoxygenase (5-LO) has been reported to be highly expressed in brain tumors and to promote glioma cell proliferation. Therefore, we investigated the anticancer activity of the novel 5-LO inhibitor derivative 3-tridecyl-4,5-dimethoxybenzene-1,2-diol hydroquinone (EA-100C red) on glioblastoma (GBM)...

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Detalles Bibliográficos
Autores principales: Zappavigna, Silvia, Cossu, Alessia Maria, Abate, Marianna, Misso, Gabriella, Lombardi, Angela, Caraglia, Michele, Filosa, Rosanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696486/
https://www.ncbi.nlm.nih.gov/pubmed/31390836
http://dx.doi.org/10.3390/ijms20153836

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696486/
https://www.ncbi.nlm.nih.gov/pubmed/31390836
http://dx.doi.org/10.3390/ijms20153836

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