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Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation

The p53 canonical consensus sequence is a 10-bp repeat of PuPuPuC(A/T)(A/T)GPyPyPy, separated by a spacer with up to 13 bases. C(A/T)(A/T)G is the core sequence and purine (Pu) and pyrimidine (Py) bases comprise the flanking sequence. However, in the p53 noncanonical sequences, there are many variat...

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Autores principales: Cai, Bi-He, Chao, Chung-Faye, Huang, Hsiang-Chi, Lee, Hsueh-Yi, Kannagi, Reiji, Chen, Jang-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696488/
https://www.ncbi.nlm.nih.gov/pubmed/31357595
http://dx.doi.org/10.3390/ijms20153681
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author Cai, Bi-He
Chao, Chung-Faye
Huang, Hsiang-Chi
Lee, Hsueh-Yi
Kannagi, Reiji
Chen, Jang-Yi
author_facet Cai, Bi-He
Chao, Chung-Faye
Huang, Hsiang-Chi
Lee, Hsueh-Yi
Kannagi, Reiji
Chen, Jang-Yi
author_sort Cai, Bi-He
collection PubMed
description The p53 canonical consensus sequence is a 10-bp repeat of PuPuPuC(A/T)(A/T)GPyPyPy, separated by a spacer with up to 13 bases. C(A/T)(A/T)G is the core sequence and purine (Pu) and pyrimidine (Py) bases comprise the flanking sequence. However, in the p53 noncanonical sequences, there are many variations, such as length of consensus sequence, variance of core sequence or flanking sequence, and variance in number of bases making up the spacer or AT gap composition. In comparison to p53, the p53 family members p63 and p73 have been found to have more tolerance to bind and activate several of these noncanonical sequences. The p53 protein forms monomers, dimers, and tetramers, and its nonspecific binding domain is well-defined; however, those for p63 or p73 are still not fully understood. Study of p63 and p73 structure to determine the monomers, dimers or tetramers to bind and regulate noncanonical sequence is a new challenge which is crucial to obtaining a complete picture of structure and function in order to understand how p63 and p73 regulate genes differently from p53. In this review, we will summarize the rules of p53 family non-canonical sequences, especially focusing on the structure of p53 family members in the regulation of specific target genes. In addition, we will compare different software programs for prediction of p53 family responsive elements containing parameters with canonical or non-canonical sequences.
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spelling pubmed-66964882019-09-05 Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation Cai, Bi-He Chao, Chung-Faye Huang, Hsiang-Chi Lee, Hsueh-Yi Kannagi, Reiji Chen, Jang-Yi Int J Mol Sci Review The p53 canonical consensus sequence is a 10-bp repeat of PuPuPuC(A/T)(A/T)GPyPyPy, separated by a spacer with up to 13 bases. C(A/T)(A/T)G is the core sequence and purine (Pu) and pyrimidine (Py) bases comprise the flanking sequence. However, in the p53 noncanonical sequences, there are many variations, such as length of consensus sequence, variance of core sequence or flanking sequence, and variance in number of bases making up the spacer or AT gap composition. In comparison to p53, the p53 family members p63 and p73 have been found to have more tolerance to bind and activate several of these noncanonical sequences. The p53 protein forms monomers, dimers, and tetramers, and its nonspecific binding domain is well-defined; however, those for p63 or p73 are still not fully understood. Study of p63 and p73 structure to determine the monomers, dimers or tetramers to bind and regulate noncanonical sequence is a new challenge which is crucial to obtaining a complete picture of structure and function in order to understand how p63 and p73 regulate genes differently from p53. In this review, we will summarize the rules of p53 family non-canonical sequences, especially focusing on the structure of p53 family members in the regulation of specific target genes. In addition, we will compare different software programs for prediction of p53 family responsive elements containing parameters with canonical or non-canonical sequences. MDPI 2019-07-27 /pmc/articles/PMC6696488/ /pubmed/31357595 http://dx.doi.org/10.3390/ijms20153681 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cai, Bi-He
Chao, Chung-Faye
Huang, Hsiang-Chi
Lee, Hsueh-Yi
Kannagi, Reiji
Chen, Jang-Yi
Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation
title Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation
title_full Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation
title_fullStr Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation
title_full_unstemmed Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation
title_short Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation
title_sort roles of p53 family structure and function in non-canonical response element binding and activation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696488/
https://www.ncbi.nlm.nih.gov/pubmed/31357595
http://dx.doi.org/10.3390/ijms20153681
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