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Combined melatonin and poricoic acid A inhibits renal fibrosis through modulating the interaction of Smad3 and β-catenin pathway in AKI-to-CKD continuum
BACKGROUND: Acute kidney injury (AKI) is one of the major risk factors for progression to chronic kidney disease (CKD) and renal fibrosis. However, effective therapies remain poorly understood. Here, we examined the renoprotective effects of melatonin and poricoic acid A (PAA) isolated from the surf...
Autores principales: | Chen, Dan-Qian, Cao, Gang, Zhao, Hui, Chen, Lin, Yang, Tian, Wang, Ming, Vaziri, Nosratola D., Guo, Yan, Zhao, Ying-Yong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696851/ https://www.ncbi.nlm.nih.gov/pubmed/31452866 http://dx.doi.org/10.1177/2040622319869116 |
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