Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity

Neurons face the challenge of maintaining cellular homeostasis through lysosomal degradation. While enzymatically active degradative lysosomes are enriched in the soma, their axonal trafficking and positioning and impact on axonal physiology remain elusive. Here, we characterized axon-targeted deliv...

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Detalles Bibliográficos
Autores principales: Farfel-Becker, Tamar, Roney, Joseph C., Cheng, Xiu-Tang, Li, Sunan, Cuddy, Sean R., Sheng, Zu-Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696943/
https://www.ncbi.nlm.nih.gov/pubmed/31269450
http://dx.doi.org/10.1016/j.celrep.2019.06.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696943/
https://www.ncbi.nlm.nih.gov/pubmed/31269450
http://dx.doi.org/10.1016/j.celrep.2019.06.013

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