Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway

The human islet amyloid polypeptide (hIAPP), the major component of islet amyloid deposition, is one of the amyloidogenic peptides and has been associated with β cell loss and dysfunction in type 2 diabetes (T2D). Autophagy plays a central role in the clearance of hIAPP aggregates, thereby diminishi...

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Detalles Bibliográficos
Autores principales: Lin, Jianzhen, Jiao, Ao, Lv, Wu, Zhang, Chengshuo, Shi, Yue, Yang, Zhaoming, Sun, Ning, Li, Xiaohang, Zhang, Jialin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697068/
https://www.ncbi.nlm.nih.gov/pubmed/31447682
http://dx.doi.org/10.3389/fphar.2019.00896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697068/
https://www.ncbi.nlm.nih.gov/pubmed/31447682
http://dx.doi.org/10.3389/fphar.2019.00896

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