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Enrichment drives emergence of functional columns and improves sensory coding in the whisker map in L2/3 of mouse S1

Sensory maps in layer (L) 2/3 of rodent cortex lack precise functional column boundaries, and instead exhibit locally heterogeneous (salt-and-pepper) tuning superimposed on smooth global topography. Could this organization be a byproduct of impoverished experience in laboratory housing? We compared...

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Autores principales: LeMessurier, Amy M, Laboy-Juárez, Keven J, McClain, Kathryn, Chen, Shilin, Nguyen, Theresa, Feldman, Daniel E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697414/
https://www.ncbi.nlm.nih.gov/pubmed/31418693
http://dx.doi.org/10.7554/eLife.46321
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author LeMessurier, Amy M
Laboy-Juárez, Keven J
McClain, Kathryn
Chen, Shilin
Nguyen, Theresa
Feldman, Daniel E
author_facet LeMessurier, Amy M
Laboy-Juárez, Keven J
McClain, Kathryn
Chen, Shilin
Nguyen, Theresa
Feldman, Daniel E
author_sort LeMessurier, Amy M
collection PubMed
description Sensory maps in layer (L) 2/3 of rodent cortex lack precise functional column boundaries, and instead exhibit locally heterogeneous (salt-and-pepper) tuning superimposed on smooth global topography. Could this organization be a byproduct of impoverished experience in laboratory housing? We compared whisker map somatotopy in L2/3 and L4 excitatory cells of somatosensory (S1) cortex in normally housed vs. tactile-enriched mice, using GCaMP6s imaging. Normally housed mice had a dispersed, salt-and-pepper whisker map in L2/3, but L4 was more topographically precise. Enrichment (P21 to P46-71) sharpened whisker tuning and decreased, but did not abolish, local tuning heterogeneity. In L2/3, enrichment strengthened and sharpened whisker point representations, and created functional boundaries of tuning similarity and noise correlations at column edges. Thus, enrichment drives emergence of functional columnar topography in S1, and reduces local tuning heterogeneity. These changes predict better touch detection by neural populations within each column.
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spelling pubmed-66974142019-08-19 Enrichment drives emergence of functional columns and improves sensory coding in the whisker map in L2/3 of mouse S1 LeMessurier, Amy M Laboy-Juárez, Keven J McClain, Kathryn Chen, Shilin Nguyen, Theresa Feldman, Daniel E eLife Neuroscience Sensory maps in layer (L) 2/3 of rodent cortex lack precise functional column boundaries, and instead exhibit locally heterogeneous (salt-and-pepper) tuning superimposed on smooth global topography. Could this organization be a byproduct of impoverished experience in laboratory housing? We compared whisker map somatotopy in L2/3 and L4 excitatory cells of somatosensory (S1) cortex in normally housed vs. tactile-enriched mice, using GCaMP6s imaging. Normally housed mice had a dispersed, salt-and-pepper whisker map in L2/3, but L4 was more topographically precise. Enrichment (P21 to P46-71) sharpened whisker tuning and decreased, but did not abolish, local tuning heterogeneity. In L2/3, enrichment strengthened and sharpened whisker point representations, and created functional boundaries of tuning similarity and noise correlations at column edges. Thus, enrichment drives emergence of functional columnar topography in S1, and reduces local tuning heterogeneity. These changes predict better touch detection by neural populations within each column. eLife Sciences Publications, Ltd 2019-08-16 /pmc/articles/PMC6697414/ /pubmed/31418693 http://dx.doi.org/10.7554/eLife.46321 Text en © 2019, LeMessurier et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
LeMessurier, Amy M
Laboy-Juárez, Keven J
McClain, Kathryn
Chen, Shilin
Nguyen, Theresa
Feldman, Daniel E
Enrichment drives emergence of functional columns and improves sensory coding in the whisker map in L2/3 of mouse S1
title Enrichment drives emergence of functional columns and improves sensory coding in the whisker map in L2/3 of mouse S1
title_full Enrichment drives emergence of functional columns and improves sensory coding in the whisker map in L2/3 of mouse S1
title_fullStr Enrichment drives emergence of functional columns and improves sensory coding in the whisker map in L2/3 of mouse S1
title_full_unstemmed Enrichment drives emergence of functional columns and improves sensory coding in the whisker map in L2/3 of mouse S1
title_short Enrichment drives emergence of functional columns and improves sensory coding in the whisker map in L2/3 of mouse S1
title_sort enrichment drives emergence of functional columns and improves sensory coding in the whisker map in l2/3 of mouse s1
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697414/
https://www.ncbi.nlm.nih.gov/pubmed/31418693
http://dx.doi.org/10.7554/eLife.46321
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