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Impact of mammalian cell culture conditions on monoclonal antibody charge heterogeneity: an accessory monitoring tool for process development

Recombinant monoclonal antibodies are predominantly produced in mammalian cell culture bioprocesses. Post-translational modifications affect the micro-heterogeneity of the product and thereby influence important quality attributes, such as stability, solubility, pharmacodynamics and pharmacokinetics...

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Detalles Bibliográficos
Autores principales: Sissolak, Bernhard, Lingg, Nico, Sommeregger, Wolfgang, Striedner, Gerald, Vorauer-Uhl, Karola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697719/
https://www.ncbi.nlm.nih.gov/pubmed/31175523
http://dx.doi.org/10.1007/s10295-019-02202-5