A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents

PURPOSE: Poor adherence to dietary/behaviour modifications as interventions for hypercholesterolemia in paediatric patients often necessitates the initiation of statin therapy. The aim of this study was to develop a joint population pharmacokinetic model for simvastatin and four metabolites in child...

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Detalles Bibliográficos
Autores principales: Ogungbenro, Kayode, Wagner, Jonathan B., Abdel-Rahman, Susan, Leeder, J. Steven, Galetin, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Pharmacokinetics and Disposition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697721/
https://www.ncbi.nlm.nih.gov/pubmed/31172248
http://dx.doi.org/10.1007/s00228-019-02697-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697721/
https://www.ncbi.nlm.nih.gov/pubmed/31172248
http://dx.doi.org/10.1007/s00228-019-02697-y

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