Generation of amine dehydrogenases with increased catalytic performance and substrate scope from ε-deaminating L-Lysine dehydrogenase

Amine dehydrogenases (AmDHs) catalyse the conversion of ketones into enantiomerically pure amines at the sole expense of ammonia and hydride source. Guided by structural information from computational models, we create AmDHs that can convert pharmaceutically relevant aromatic ketones with conversion...

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Detalles Bibliográficos
Autores principales: Tseliou, Vasilis, Knaus, Tanja, Masman, Marcelo F., Corrado, Maria L., Mutti, Francesco G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697735/
https://www.ncbi.nlm.nih.gov/pubmed/31420547
http://dx.doi.org/10.1038/s41467-019-11509-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697735/
https://www.ncbi.nlm.nih.gov/pubmed/31420547
http://dx.doi.org/10.1038/s41467-019-11509-x

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