Cargando…

Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4(+) T Cells

CD4(+) T cells are essential for immune protection against viruses, yet their multiple roles remain ill-defined at the single-cell level in humans. Using HLA class II tetramers, we studied the functional properties and clonotypic architecture of EBV-specific CD4(+) T cells in patients with infectiou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meckiff, Benjamin J., Ladell, Kristin, McLaren, James E., Ryan, Gordon B., Leese, Alison M., James, Eddie A., Price, David A., Long, Heather M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2019
Materias:	Infectious Disease and Host Response
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697742/ https://www.ncbi.nlm.nih.gov/pubmed/31308093 http://dx.doi.org/10.4049/jimmunol.1900377

Ejemplares similares

Stochastic Expansions Maintain the Clonal Stability of CD8(+) T Cell Populations Undergoing Memory Inflation Driven by Murine Cytomegalovirus
por: Smith, Corinne J., et al.
Publicado: (2020)

Cytotoxic Mediators in Paradoxical HIV–Tuberculosis Immune Reconstitution Inflammatory Syndrome
por: Wilkinson, Katalin A., et al.
Publicado: (2015)

Terminal Effector CD8 T Cells Defined by an IKZF2(+)IL-7R(−) Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity
por: Naluyima, Prossy, et al.
Publicado: (2019)

The Cellular Localization of Human Cytomegalovirus Glycoprotein Expression Greatly Influences the Frequency and Functional Phenotype of Specific CD4(+) T Cell Responses
por: Pachnio, Annette, et al.
Publicado: (2015)

CD4(+) T Cell Responses to the Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with Mild Malaria
por: Gitau, Evelyn N., et al.
Publicado: (2014)

Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity
por: Lindau, Paul, et al.
Publicado: (2019)

PI3Kδ Regulates the Magnitude of CD8(+) T Cell Responses after Challenge with Listeria monocytogenes
por: Pearce, Verity Q., et al.
Publicado: (2015)

Hif-1α–Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish
por: Ogryzko, Nikolay V., et al.
Publicado: (2019)

Exhausted CD4(+) T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression
por: Villegas-Mendez, Ana, et al.
Publicado: (2020)

A Requirement for Neutrophil Glycosaminoglycans in Chemokine:Receptor Interactions Is Revealed by the Streptococcal Protease SpyCEP
por: Goldblatt, Jennifer, et al.
Publicado: (2019)

Cysteine-Reactive Free ISG15 Generates IL-1β–Producing CD8α(+) Dendritic Cells at the Site of Infection
por: Napolitano, Anna, et al.
Publicado: (2018)

Control of Viremia Enables Acquisition of Resting Memory B Cells with Age and Normalization of Activated B Cell Phenotypes in HIV-Infected Children
por: Muema, Daniel M., et al.
Publicado: (2015)

The Threshold of Protection from Liver-Stage Malaria Relies on a Fine Balance between the Number of Infected Hepatocytes and Effector CD8(+) T Cells Present in the Liver
por: Spencer, Alexandra J., et al.
Publicado: (2017)

Delinking CARD9 and IL-17: CARD9 Protects against Candida tropicalis Infection through a TNF-α–Dependent, IL-17–Independent Mechanism
por: Whibley, Natasha, et al.
Publicado: (2015)

Characterizing the Mechanisms of Nonopsonic Uptake of Cryptococci by Macrophages
por: Lim, Jenson, et al.
Publicado: (2018)

MyD88 Signaling Inhibits Protective Immunity to the Gastrointestinal Helminth Parasite Heligmosomoides polygyrus
por: Reynolds, Lisa A., et al.
Publicado: (2014)

IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance
por: Patin, Emmanuel C., et al.
Publicado: (2016)

Type I IFN Induces IL-10 Production in an IL-27–Independent Manner and Blocks Responsiveness to IFN-γ for Production of IL-12 and Bacterial Killing in Mycobacterium tuberculosis–Infected Macrophages
por: McNab, Finlay W., et al.
Publicado: (2014)

T Cell Immunity to the Alkyl Hydroperoxide Reductase of Burkholderia pseudomallei: A Correlate of Disease Outcome in Acute Melioidosis
por: Reynolds, Catherine, et al.
Publicado: (2015)

Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans
por: Currie, Silke M., et al.
Publicado: (2016)

Mapping the Binding Site of a Cross-Reactive Plasmodium falciparum PfEMP1 Monoclonal Antibody Inhibitory of ICAM-1 Binding
por: Lennartz, Frank, et al.
Publicado: (2015)

Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling
por: Moreira-Teixeira, Lúcia, et al.
Publicado: (2016)

Dichotomy between T Cell and B Cell Tolerance to Neonatal Retroviral Infection Permits T Cell Therapy
por: Mavrommatis, Bettina, et al.
Publicado: (2016)

Egr2 and 3 Inhibit T-bet–Mediated IFN-γ Production in T Cells
por: Singh, Randeep, et al.
Publicado: (2017)

T Cell–Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection
por: Moreira-Teixeira, Lúcia, et al.
Publicado: (2017)

Monocyte Adhesion, Migration, and Extracellular Matrix Breakdown Are Regulated by Integrin αVβ3 in Mycobacterium tuberculosis Infection
por: Brilha, Sara, et al.
Publicado: (2017)

Mice Deficient in T-bet Form Inducible NO Synthase–Positive Granulomas That Fail to Constrain Salmonella
por: Perez-Toledo, Marisol, et al.
Publicado: (2020)

Nontypeable Haemophilus influenzae P5 Binds Human C4b-Binding Protein, Promoting Serum Resistance
por: Thofte, Oskar, et al.
Publicado: (2021)

Vaccinia Virus Infection Inhibits Skin Dendritic Cell Migration to the Draining Lymph Node
por: Aggio, Juliana Bernardi, et al.
Publicado: (2021)

Cyclooxygenase-Derived Prostaglandin E(2) Drives IL-1–Independent Mycobacterium bovis Bacille Calmette-Guérin–Triggered Skin Dendritic Cell Migration to Draining Lymph Node
por: Krmeská, Veronika, et al.
Publicado: (2022)

Group 2 Innate Lymphoid Cells Are Detrimental to the Control of Infection with Francisella tularensis
por: Dow, Joshua, et al.
Publicado: (2023)

Retinoic Acid–Related Orphan Receptor α Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation
por: Roberts, Joseph, et al.
Publicado: (2023)

Activation of the Endoplasmic Reticulum Stress Response Impacts the NOD1 Signaling Pathway
por: Mendez, Jonathan M., et al.
Publicado: (2019)

Physician Use of Multiple Criteria to Diagnose Periprosthetic Joint Infection May Be Less Accurate Than the Use of an Individual Test
por: Deirmengian, Carl, et al.
Publicado: (2022)

OT-1 mice display minimal upper genital tract pathology following primary intravaginal Chlamydia muridarum infection
por: Manam, Srikanth, et al.
Publicado: (2013)

Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells
por: Forbester, Jessica L., et al.
Publicado: (2015)

Neonatal Fc Receptor Regulation of Lung Immunoglobulin and CD103(+) Dendritic Cells Confers Transient Susceptibility to Tuberculosis
por: Vogelzang, Alexis, et al.
Publicado: (2016)

Particles from the Echinococcus granulosus Laminated Layer Inhibit CD40 Upregulation in Dendritic Cells by Interfering with Akt Activation
por: Pittini, Álvaro, et al.
Publicado: (2019)

Mitigating Concerns Over Transport Delays: An Analysis of Synovial Fluid Culture Results in Arthroplasty
por: Deirmengian, Carl, et al.
Publicado: (2023)

Context-Dependent Roles for Toll-Like Receptors 2 and 9 in the Pathogenesis of Staphylococcus aureus Osteomyelitis
por: Petronglo, Jenna R., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qu42fu145no8etmkej3r49ldjv