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miR-504 suppresses mesenchymal phenotype of glioblastoma by directly targeting the FZD7-mediated Wnt–β-catenin pathway

BACKGROUND: MicroRNAs (miRNAs) play crucial roles in tumor initiation and development. Previously, we indicated that miR-504 is downregulated and suppresses tumor proliferation in glioblastoma (GBM). However, the regulation and relevant mechanism of miR-504 in GBM mesenchymal (ME) transition remain...

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Detalles Bibliográficos
Autores principales: Liu, Qiang, Guan, Yanlei, Li, Zhenhang, Wang, Yao, Liu, Yu, Cui, Run, Wang, Yunjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697940/
https://www.ncbi.nlm.nih.gov/pubmed/31419987
http://dx.doi.org/10.1186/s13046-019-1370-1